Veterinary Cardiac Genetics Laboratory
PO Box 605, Pullman, WA 99163-0605
509-335-6038 • FAX: 509-335-3745 • firstname.lastname@example.org
EVALUATION FOR THE FELINE HYPERTROPHIC CARDIOMYOPATHY
CARDIAC MYOSIN BINDING PROTEIN C MUTATION
Hypertrophic cardiomyopathy is the most common form of heart disease in the cat. In many breeds it is an inherited
disease. Our laboratory has identified a mutation responsible for the gene in some cats. However, it should be noted that
in human beings with the same disease, there are many different genetic mutations which can cause this disease. It is likely
the same in the cat.
Very importantly, the absence of the mutation in this cat DOES NOT mean that it will never develop the disease.
It means that it does not have the only known mutation that can cause the disease in the cat at this time. In the future, additional mutations may be identified that may be tested for as well.
Cats that are positive for the test will not necessarily develop significant heart disease and die from the disease. Some cats will develop a very mild form of the disease
and will live quite comfortably. We recommend annual evaluation by an echocardiogram and discussion with a veterinarian for
treatment options if hypertrophy develops.
Importantly, breeding decisions should be made carefully. At this time we have observed about 35% Maine Coon
cats that we have tested carry at least one copy of the gene. Removal of all of these cats from the breeding population could
be very bad for the Maine Coon breed. Remember that HCM affected cats also carry other important good genes that we do not
want to lose from the breed. We recommend not breeding the homozygous cats and, if needed, breeding heterozygotes to unaffected
cats to decrease the risk of producing affected cats. As we move forward we should try to select more and more negative kittens
from these lines to use for breeding. Keep in mind that we are continually learning about this disease and recommendations
will be altered as we obtain more information.
Date: August 30, 2006
Cat Name: Hillside Cheyenne of Tribalcats
Cat Breed: Maine Coon
Microchip Number (optional):
Owner Name: Valerie Walter
The results of this test are:
Negative for the HCM mutation
Kathryn M. Meurs, DVM, PhD, Professor
Richard L. Ott Chair of Small Animal Medicine and Research
Washington State University- College of Veterinary Medicine